Uniprot MCP Server

A Model Context Protocol (MCP) server that provides access to UniProt protein information. This server allows AI assistants to fetch protein function

Local serverstdioPython

What is the Uniprot MCP server?

Uniprot mcp server lets Claude, Cursor and other MCP clients work with Uniprot directly. A Model Context Protocol (MCP) server that provides access to UniProt protein information. This server allows AI assistants to fetch protein function and sequence information directly from UniProt.

What Uniprot does

A Model Context Protocol (MCP) server that provides access to UniProt protein information. This server allows AI assistants to fetch protein function and sequence information directly from UniProt.

Key capabilities

  • Get protein information by UniProt accession number
  • Batch retrieval of multiple proteins
  • Caching for improved performance (24-hour TTL)
  • Error handling and logging
  • Information includes:
  • Function description
  • Full sequence
  • Sequence length

Tools it exposes

Once connected, the assistant can call this tool directly:

  • Tools — 1. get_protein_info - Get information for a single protein - Required parameter: accession (UniProt accession number) - Example response: json { "accession"

Installing the uniprot mcp server

Setup follows the standard MCP pattern: clone or install the server, then register it in your client's configuration file and restart the client. The configuration snippets on this page cover Claude Desktop, Claude Code and Cursor.

Where it fits

Developer-tool servers are usually the first ones people connect, because they turn "help me with this code" into an assistant that can actually read the repo and act on it. Uniprot sits in that group, and the shape of its toolset — Tools — tells you what it is really for. Worth comparing against the other developer tools servers in this directory before you commit to one, since several overlap in scope but differ sharply in setup cost and permissions.

Practical notes

  • This server runs locally, so it operates with whatever access your machine and its credentials already have. Scope that deliberately rather than by default.
  • Maintained by TakumiY235, written in Python.
  • MCP clients ask for confirmation before each tool call by default. Keep that on while you learn what the uniprot mcp server actually does with your data.
  • Every entry in this directory is reviewed by hand before it goes live, and details are checked against the project's own documentation.

Available tools

ToolWhat it does
Tools1. get_protein_info - Get information for a single protein - Required parameter: accession (UniProt accession number) - Example response: json { "accession": "P12345", "protein_name": "Example protein", "function": ["Des

How to install the Uniprot MCP server

{
  "mcpServers": {
    "uniprot": {
      "command": "uv",
      "args": ["--directory", "path/to/uniprot-mcp-server", "run", "uniprot-mcp-server"]
    }
  }
}

Configuration as documented by the project. Restart the client after saving.

Example prompts to try

  • Use Uniprot to Tools.

Frequently asked questions

It connects Uniprot to MCP-compatible AI assistants such as Claude and Cursor, exposing 1 tool (Tools) that the assistant can call on your behalf. Instead of copying data back and forth by hand, the assistant works with Uniprot directly.