A high-performance unified Model Context Protocol (MCP) server that enables Claude Desktop to search for clinical trial matches on clinicaltrials.gov based on genetic mutations.
Mutation Clinical Trial Matching MCP is an MCP project maintained in the pickleton89/mutation-clinical-trial-matching-mcp repository. The maintainer describes its purpose as “A high-performance unified Model Context Protocol (MCP) server that enables Claude Desktop to search for clinical trial matches on clinicaltrials.gov based on genetic mutations”. Read the project documentation for the complete scope.
The project provides a local client configuration using uv. Follow the repository’s build and installation steps before copying it, and replace example paths with the paths on your own computer.
Project documentation · Repository · Discovery listing. This profile records the public documentation checked on 2026-10-08.
{
"mcpServers": {
"mutation-clinical-trials-mcp": {
"command": "uv",
"args": [
"run",
"python",
"servers/main.py"
],
"description": "Unified clinical trials matching server with runtime mode selection"
}
}
}From the project documentation. Replace placeholders and example paths before connecting.
Enables analysis of clinical trial data from the AACT database, tracking development trends, and generating analysis memos.
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