Reactome MCP Server

Production-ready MCP server for Reactome pathway and systems biology data - Developed by Augmented Nature

Local serverstdioTypeScript

What is the Reactome MCP server?

If you already use Reactome, the reactome mcp server is the piece that lets your assistant work with it directly. Production-ready MCP server for Reactome pathway and systems biology data - Developed by Augmented Nature.

What the server does

Model Context Protocol server for accessing Reactome pathway and systems biology data.

Available tools

The toolset is worth reading before you wire it up, because it tells you what the integration is really for:

  • Version — Reactome v79 (latest)
  • Authentication — None required
  • Format — REST API with JSON responses

Installation

Installation goes through your MCP client rather than a global install: point it at npm on npm and it is fetched when the client starts. The copy-paste blocks for Claude Desktop, Claude Code and Cursor are further down this page.

Where it fits

Among the developer tooling options, the useful question is rarely "what can it do" but "what does it cost you to run" — permissions, credentials, and how much of your context its toolset consumes. Reactome's toolset — Version, Authentication, Format — is a fair guide to whether it matches your workflow. It is maintained by Augmented-Nature; worth a glance at recent repository activity before you build anything load-bearing on it.

SyncDev reviews every entry in this directory against the project's own documentation before publishing, and revisits them as servers change.

Worth knowing first

  • It runs with your machine's permissions. That is convenient and also the reason to think about what you point it at before you approve a tool call.
  • Keep per-call confirmation enabled while you learn its behaviour; it is the cheapest safeguard you have.

Available tools

ToolWhat it does
VersionReactome v79 (latest)
AuthenticationNone required
FormatREST API with JSON responses

How to install the Reactome MCP server

{
  "mcpServers": {
    "reactome": {
      "command": "npx",
      "args": ["-y", "npm"]
    }
  }
}

Add to claude_desktop_config.json, then restart Claude Desktop.

Example prompts to try

  • Use Reactome to Version.
  • Use Reactome to Authentication.
  • Use Reactome to Format.

Frequently asked questions

It connects Reactome to MCP-compatible AI assistants such as Claude and Cursor, exposing 3 tools (Version, Authentication, Format) that the assistant can call on your behalf. Instead of copying data back and forth by hand, the assistant works with Reactome directly.