Uniprot Mcp MCP Server

GitHub repo: fzlzjerry/uniprot-mcp · PyPI package & command: uniprotkb-mcp (the Python import package is uniprot_mcp).

Local serverstdio

What is the Uniprot Mcp Server?

Uniprot Mcp is an MCP project maintained in the fzlzjerry/uniprot-mcp repository. The maintainer describes its purpose as “GitHub repo: fzlzjerry/uniprot-mcp · PyPI package & command: uniprotkb-mcp (the Python import package is uniprot_mcp)”. Read the project documentation for the complete scope.

Installation

The documented pypi package is uniprotkb-mcp. The configuration below comes from the maintainer’s example; adapt its paths and account values to your environment.

Configuration values

The example declares UNIPROT_MCP_CONTACT. Secret-looking values have been replaced with placeholders. Required and optional labels are shown only when the documentation states them.

Source

Project documentation · Repository · Discovery listing. This profile records the public documentation checked on 2026-10-08.

Recorded tools

Check the linked publisher documentation and your connected client's tool list. Names and availability can vary with the server version and account permissions.

ToolWhat it does
search_uniprotkbSearch UniProtKB with native query syntax. reviewed / organism_id filters are added for you. Summary, FASTA, or TSV output.
get_entryOne entry as a curated digest (function, names, organism, length, subcellular location, family/domains, key features, PTMs, keywords…
get_fastaRaw FASTA for one accession or a batch.
map_idsConvert ids across databases via UniProt's async ID-mapping (e.g. RefSeq_Protein→UniProtKB, UniProtKB_AC-ID→PDB). Returns mapped pairs and unmapped ids…
get_taxonomyResolve an organism name or taxon id → taxon id, names, rank, lineage. Turn "human" into organism_id:9606.
search_unirefSearch UniRef100/90/50 sequence-similarity clusters.
search_proteomesSearch proteomes (whole-organism protein sets); reference-proteome filter.

How to install the Uniprot Mcp Server

{
  "mcpServers": {
    "uniprot": {
      "command": "uvx",
      "args": [
        "uniprotkb-mcp"
      ],
      "env": {
        "UNIPROT_MCP_CONTACT": "you@example.org"
      }
    }
  }
}

From the project documentation. Replace placeholders and example paths before connecting.

Configuration

VariableDescriptionRequired
UNIPROT_MCP_CONTACTDeclared in the maintainer’s client configuration.Check documentation