Bio MCP Bwa MCP Server

MCP (Model Context Protocol) server for the BWA (Burrows-Wheeler Aligner) sequence alignment tool.

Local serverstdioPython

What is the Bio MCP Bwa MCP server?

If you already use Bio MCP Bwa, the bio mcp bwa mcp server is the piece that lets your assistant work with it directly. MCP (Model Context Protocol) server for the BWA (Burrows-Wheeler Aligner) sequence alignment tool.

What the server does

This MCP server provides access to BWA functionality, allowing AI assistants to perform alignment of short and long sequencing reads to a reference genome.

  • bwa_index — Create an index for a reference genome
  • bwa_mem — Align reads using the BWA-MEM algorithm
  • bwa_aln — Find SA coordinates with the BWA-backtrack algorithm
  • bwa_samse — Generate single-end alignments in SAM format
  • bwa_sampe — Generate paired-end alignments in SAM format
  • Support for large reference genomes and read files

Available tools

The toolset is worth reading before you wire it up, because it tells you what the integration is really for:

  • Prerequisites — The Prerequisites tool exposed by this server

Credentials and setup notes

Configuration is passed through the environment: BIO_MCP_BWA_PATH. Treat anything key-shaped as a real credential — scope it to the minimum the server needs, and rotate it if it ever lands in a shared config.

  • Python 3.9+ - BWA installed (bwa)

Installation

Setup follows the usual MCP pattern — install or clone the server, register it in your client's configuration file, restart the client. The configuration blocks on this page cover the common clients.

Where it fits

This sits in the developer tooling group, where several servers overlap in what they claim to do but differ sharply once you actually set them up. Bio MCP Bwa's toolset — Prerequisites — is a fair guide to whether it matches your workflow. It is maintained by bio-mcp; worth a glance at recent repository activity before you build anything load-bearing on it.

This entry was verified against Bio MCP Bwa's own documentation before publication; SyncDev keeps the directory reviewed rather than auto-generated.

Worth knowing first

  • It runs with your machine's permissions. That is convenient and also the reason to think about what you point it at before you approve a tool call.
  • Keep per-call confirmation enabled while you learn its behaviour; it is the cheapest safeguard you have.

Available tools

ToolWhat it does
PrerequisitesThe Prerequisites tool exposed by this server.

How to install the Bio MCP Bwa MCP server

{
  "mcpServers": {
    "bio-bwa": {
      "command": "python",
      "args": ["-m", "src.server"],
      "cwd": "/path/to/bio-mcp-bwa"
    }
  }
}

Configuration as documented by the project. Restart the client after saving.

Configuration

  • Python 3.9+ - BWA installed (bwa)
VariableDescriptionRequired
BIO_MCP_BWA_PATHFilesystem location the server is allowed to use.Optional

Example prompts to try

  • Use Bio MCP Bwa to Prerequisites.

Frequently asked questions

It connects Bio MCP Bwa to MCP-compatible AI assistants such as Claude and Cursor, exposing 1 tool (Prerequisites) that the assistant can call on your behalf. Instead of copying data back and forth by hand, the assistant works with Bio MCP Bwa directly.