Unofficial UniProt MCP Server

A comprehensive Model Context Protocol (MCP) server providing advanced access to the UniProt protein database.

Local serverstdioTypeScript

What is the Unofficial UniProt MCP server?

Most database access work still happens through a UI a human drives. Unofficial UniProt MCP server moves it into the conversation instead. A comprehensive Model Context Protocol (MCP) server providing advanced access to the UniProt protein database.

The short version

A comprehensive Model Context Protocol (MCP) server providing advanced access to the UniProt protein database. This server offers 26 specialized bioinformatics tools enabling AI assistants and MCP clients to perform sophisticated protein research, comparative genomics, structural biology analysis, and systems biology investigations directly through UniProt's REST API.

This comprehensive UniProt MCP Server is developed by Augmented Nature, a leading innovator in AI-powered bioinformatics and computational biology solutions. Augmented Nature specializes in creating advanced tools that bridge the gap between artificial intelligence and biological research, enabling researchers to unlock deeper insights from biological data.

The tools it exposes

The server publishes 5 tools. What each one is for:

  • Gene — based Search**: Find proteins by gene name or symbol
  • User-Agent — UniProt-MCP-Server/1.0.0
  • Timeout — 30 seconds
  • Prerequisites — The Prerequisites tool exposed by this server
  • Setup — The Setup tool exposed by this server

Getting it running

Setup follows the usual MCP pattern — install or clone the server, register it in your client's configuration file, restart the client.

What it needs from you

  • Node.js (v16 or higher) - npm or yarn

How it compares

This sits in the database access group, where several servers overlap in what they claim to do but differ sharply once you actually set them up. Unofficial UniProt's toolset — Gene, User-Agent, Timeout and 2 more — is a fair guide to whether it matches your workflow. It is maintained by Augmented-Nature; worth a glance at recent repository activity before you build anything load-bearing on it.

We check each listing at SyncDev against the project's documentation before it goes live — if something here drifts out of date, it is a bug worth reporting.

Things to watch

  • It runs with your machine's permissions. That is convenient and also the reason to think about what you point it at before you approve a tool call.
  • Keep per-call confirmation enabled while you learn its behaviour; it is the cheapest safeguard you have.

Available tools

ToolWhat it does
Genebased Search**: Find proteins by gene name or symbol
User-AgentUniProt-MCP-Server/1.0.0
Timeout30 seconds
PrerequisitesThe Prerequisites tool exposed by this server.
SetupThe Setup tool exposed by this server.

Configuration

  • Node.js (v16 or higher) - npm or yarn

Example prompts to try

  • Use Unofficial UniProt to Gene.
  • Use Unofficial UniProt to User-Agent.
  • Use Unofficial UniProt to Timeout.

Frequently asked questions

Node.js v16 or higher and npm or yarn are required.