Nullary is a hosted MCP server that lets AI agents query measured negative results from drug discovery: inactive compounds, failed selectivity panels, terminated clinical trials, failed CRISPR…
Nullary - Negative Results Intelligence For Drug Discovery is an MCP project maintained in the nullary-ai/nullary-mcp repository. The maintainer describes its purpose as “Nullary is a hosted MCP server that lets AI agents query measured negative results from drug discovery: inactive compounds, failed selectivity panels, terminated clinical trials…”. Read the project documentation for the complete scope.
The maintainer’s configuration uses https://mcp.nullary.ai/mcp. Check the project’s account and authentication instructions when adding the endpoint to your client.
Project documentation · Repository · Discovery listing. This profile records the public documentation checked on 2026-10-08.
Check the linked publisher documentation and your connected client's tool list. Names and availability can vary with the server version and account permissions.
| Tool | What it does |
|---|---|
| search_inactive_compounds | Inactive small-molecule compound-target pairs. |
| search_failed_selectivity | Small molecules that failed selectivity. |
| search_admet_failures | Small-molecule ADMET failures. |
| search_failed_guides | Failed/ineffective CRISPR guides. |
| search_failed_essentiality_screens | Non-dependency / failed essentiality screens. |
| search_ancestry_specific_failures | Ancestry-specific CRISPR failures. |
| search_developability_failures | Antibody developability failures. |
| search_failed_clinical_antibodies | Discontinued/terminated clinical antibodies. |
| search_failed_peptide_therapeutics | Failed peptide therapeutics. |
| search_peptide_stability_issues | Peptide stability/half-life failures. |
| search_failed_protacs | PROTACs that failed degradation/ternary/permeability. |
| search_protac_e3_issues | PROTAC E3-ligase recruitment / ternary failures. |
| search_failed_oligonucleotides | ASOs/siRNAs that failed engagement/developability. |
| search_oligo_delivery_failures | Oligonucleotide delivery failures. |
| search_failed_vaccines | Failed/terminated vaccines (by pathogen/indication). |
| search_vaccine_immunogenicity_failures | Failed vaccine immunogen designs. |
| search_failed_adcs | ADCs that failed at any stage. |
| search_adc_linker_failures | ADC failures attributed to linker chemistry. |
| search_failed_bispecifics | Bispecifics that failed at any stage. |
| search_bispecific_format_failures | Bispecific format/engineering failures. |
| search_admet_failures_all_modalities | ADMET failures across ALL modalities. |
| search_drug_drug_interaction_failures | Drug-drug interaction failures. |
| search_mechanism_failures | Approaches that failed for a mechanism (by target). |
| search_failed_replications | Findings that failed to replicate. |
| search_safety_failures | Clinical/preclinical safety failures across modalities. |
| search_target_history | ALL failed approaches against a target across every modality. |
| search_indication_history | ALL failed approaches for an indication across every modality. |
| search_pathogen_history | Vaccine + antimicrobial + antibody failures for a pathogen. |
| get_compound | A compound + its full negative profile across modalities/sources. |
| get_finding_provenance | Full provenance + detail for a single finding by id. |
| get_target_landscape | Target "graveyard" / exhaustion index — how picked-over a target is, by modality and outcome. |
| list_top_targets | The most heavily-pursued targets, ranked by recorded negative findings. |
| list_models | Summary of the Layer-1 inactivity-scoring model registry. |
| get_model_card | Per-target Layer-1 model card: training counts + held-out scaffold-split metrics. |
| get_coverage | Per-modality and per-source coverage stats. |
{
"mcpServers": {
"nullary": {
"url": "https://mcp.nullary.ai/mcp"
}
}
}From the project documentation. Replace placeholders and example paths before connecting.
Enables analysis of clinical trial data from the AACT database, tracking development trends, and generating analysis memos.
Scholarly search: OpenAlex, Crossref, arXiv, OpenCitations and PubMed in one endpoint.
View on ApifyForge | Use on Apify Store
Scholarly search: OpenAlex, Crossref, arXiv, OpenCitations and PubMed in one endpoint.
Academic research search across PubMed and arXiv
Polymarket whales & odds, hiring signals, LLC filings, GovCon recompetes, clinical trials on Apify